Large volume crystal growth in restricted geometry for neutron crystallography
نویسندگان
چکیده
منابع مشابه
Opportunities and challenges with the growth of neutron crystallography.
Neutron crystallography is a newly blossoming field of structural biology. As described in the historical account given by Benno Schoenborn in this issue, its origins can be traced back to the Cambridge MRC tearoom in 1965 when it was discussed as the only plausible experimental method for directly determining the location of H atoms in proteins. Knowing the location of H atoms can provide info...
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Neutron crystallography began to be employed at the Bhabha Atomic Research Centre (BARC), Trombay, Mumbai in the early sixties. At that time, the technique, at BARC as well as elsewhere, was in a nascent state, with emphasis on building of instruments and development of crystallography software. Over the years, the Trombay group kept pace with the advancements in other parts of world and employ...
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Preliminary phases were determined by the application of the isomorphous replacement method at low and intermediate resolution for structure factor amplitudes collected from crystals of large and small ribosomal subunits from halophilic and thermophilic bacteria. Derivatization was performed with dense heavy atom clusters, either by soaking or by specific covalent binding prior to the crystalli...
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Synchrotron radiation (SR) techniques are continuously pushing the frontiers of wavelength range usage, smaller crystal sample size, larger protein molecular weight and complexity, as well as better diffraction resolution. The new research specialism of probing functional states directly in crystals, via time-resolved Laue and freeze trapping structural studies, has been developed, with a range...
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Since drugs bind to their targets through directional H bonding and non-directional hydrophobic and electrostatic interactions, neutron crystallography can help guide structure-based drug design. This is illustrated by McKenna and co-workers [Aggarwal et al. (2016), IUCrJ, 3, 319-325] who describe the room-temperature neutron structure of human carbonic anyhydrase II in complex with the clinica...
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ژورنال
عنوان ژورنال: Acta Crystallographica Section A Foundations of Crystallography
سال: 2011
ISSN: 0108-7673
DOI: 10.1107/s0108767311081505